cxcr4在非小细胞肺癌细胞中的表达和意义

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1、重庆医科大学硕士研究生学位论文was92．68％．ExpressionofCXCR4(+)had9cases(21．95％)，CXCR4(++)hadl4cases(34．15％)，andCXCR4(+++)had15cases(36．59％)Althoughonly2of20casesofnormallungcellsexpressedCXCR4(+)，18of20casesdidnotexpressCXCR4。andthepositiveratewas10％．TheresultshowedthattherewerenosignificantdifferenceforCXC

2、R4expressioninprimarytumorcellsamongdifferentages，genders，clinicalstages．andhistologicaltypes(胗O．05)．OurresearchdidnotshowthatithadasignificantcorrelationbetweentheCXCR4expressionandtheregionallymphnodesmetastasisoccurring(P>0．05)．Furthermore，in24of25casesofregionalmetastasizedlymphnodes，th

3、ecancercellsexpressedCXCR4．Theoverallpositiveratewas96％．ExpressionofCXCR4(+)had8cases(32％)，CXCR4(++)had14cases(56％)，andCXCR4(卅)had2cases(8％)．ThestatisticanalysisdemonstratedthatthecancercellsinmetastasizedlymphnodesexpressedCXCR4waslowerthanthatinprimarysites(P

4、ofCXCR4iscommoninprimarytlllrlorcellsofNSCLC，andthereisnosignificantdifferenceforCXCR4expressioninprimarytumorcellsamongdifferenthistologicaltypes．TheseindicatethedifferenthistologicaltypeNSCLCspossiblyhavemumalorigins．2)SinceithadrevealedthatSDF一1isexpressedpreferentiallyinlymphnodes，andCX

5、CR4istheuniquereceptortoSDF-1，commonexpressionofCXCR4inprimarytumorcellsoftheNSCLCalsoindicates5重庆医科大学硕士研究生学位论文thatCXCR4probablyplaysanimportantroleininducingtargetmetastasisofcancercellstoregionallymphnodes．3)ThecancercellsinmetastasizedlymphnodesexpressCXCR4islowerthanthatinprimarysitesde

6、monstratesindirectlythatSDF一1CandowngradeexpressionofCXCR4incancercellswhenitbondstoCXCR4．Thismaybeoneofimmunityreactsofthebodytothecancer,andmaybeoneofpotentialmechanismsresultinginlymphnodesmetastasisalwaysoccurringintUlTISaswellKeyWords：nonsmallcelllungcancer；chemokineCXCmotifreceptor4；l

7、ymphnode；metastasis；immunohistochemistry6重庆医科大学硬士研究生学位论文CXCR4在非小细胞肺癌细胞中的表达及意义刖吾肿瘤的转移是恶性肿瘤重要的基本生物学特征之一。国内外大量研究证明：肿瘤的转移不是随机性的，而是有选择性的，是具有嗜器官性的“’。趋化因子是一类促炎多肽细胞因子的超家族，是能使细胞发生趋化运动的小分子细胞因子(分子量8-10I∞)01。近年来研究发现趋化因子除对白细胞亚类中的中性粒细胞、单核细胞、淋巴细胞等具有趋化作用外，对多种细胞包括内皮细胞、肿瘤