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1、宁夏医科大学硕士研究生学位论文中文摘要物敏感试验的检测，合理选择抗生素，提高临床治疗疗效，减少病原菌耐药菌株的产生。关键词新生儿,肺炎,病原菌,耐药性II万方数据宁夏医科大学硕士研究生学位论文英文摘要AnalysisofneonatalpneumoniapathogendistributionandbacterialresistanceABSTRACTObjectiveTostudythePathogenDistributionandanalyzethedrugresistanceinneonatalpneumonia,Toprovidetheguid
2、eforclinicaltherapy.MethodsAcquisitionofneonatalpneumoniainchildreninourhospitalneonatalJune2010June2013qualifiedsputumspecimenstreated,CommitteeforStandardizationinstrictaccordancewithAmericanSocietyofClinicalLaboratory(NCCLS)recommendedoperatingmethods,Susceptibilitytestinguse
3、K-Bdiskdiffusionmethod,QualitycontrolstrainsareEscherichiacoliATCC25922,StaphylococcusaureusATCC25923,AllprovidedbytheMinistryofHealth,BiologicalProducts.Referto2010-2013CommitteeforStandardizationofclinicalreferencelaboratory(CLSI)recommendedguidelinestodeterminetheresults,Acco
4、rdingtoWHONETsoftwareprogramcollecteddataentryWHONETstatisticalanalysissoftwareandbacteriadistributionanddrugresistance.ResultsTwohundredthirty-fourPlantsPathogensweredetectedfromOnethousandandninety-eightSputumculture,thePositiveratewas21.31%；withGram-negativebacteriaaccounting
5、for62.39%,ThemainbacteriaincludedEscherichiacoli,KlebsiellaandEnterobactercloacae.Gram-positivebacteriaaccountsfor37.61%,ThemainbacteriaincludedStaphylococcusaureusandStaphylococcusepidermidis;53plantsgram-negativebacilliproducedESBLs,thePositiveratewas36.30%;TheMethicillin-resi
6、stantStaphylococcusaureus'(MRSA)detectionratewas58.62%,EscherichiacolibacteriaandBacterialpneumoniaKeLeibotoampicillin,cefuroxime,cefazolin,higheraztreonam,cefepimeandampicillinsulbactamrate(43.48%~92.11%),Significantlyhigherthancefoperazonesulbactam,imipenemandmeropenem(P<0.05)
7、,EnterobactercloacaeIII万方数据宁夏医科大学硕士研究生学位论文英文摘要cefoperazonesulbactam,imipenem,levofloxacin,cefepime,amikacinwerelessthan10%,ESBLsproducingtheG-bacilliresistanttothirdgenerationcephalosporinsrateofover50%,Imipenem,meropenem,amikacinrateoflessthan4%,.Staphylococciresistanttopenicil
8、linGratiowas100%,Clindamycinandtrimethoprim-sul
