grp78和grp94在直肠腺癌中表达及意义

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1、硕士学位论文英文摘要ABSTRACTBae吨roundTheglueose一regulatedProteins(G砂)refertoasetofProteinsgeneratedbyeellinordertoadaPttoendoplasmieretieulumstress.GRP78andGRP94areimPortantmembersofthetribe，whosemainP坤siologiealfunetion15involvedinProteinsynthesiswhenthenewbomPolyPePtideehainfol

2、ding，asmoleeularehaPerones.Recentstudiesshowthat，highexPressionofGRPwasfoundinsometumoreells，theywereinvolvedeloselyinthegeneration，ProgressionandPrognosisofmalignanttumors，andsuPPlynewtheorysuPPortforelinicaldiagnosisandtreatmeniformalignanttumors.ObjeetiveTostu即theeXP

3、ressionsofGRP78andGRP94inreetaladenoeareinomaandtherelationshiPbetweenthemandtheeliniealandPathologiealfeaturesofrectaladenocareinoma，anditseliniealsignifieance·MethodsWeColleeted45easesofsurgieallyreseetedsPeeimensinrectaladenoeareinomaandtheirPericaneeroustissuesforeo

4、ntrast.SPeeimenswereeonfirmedbyPathologyexamandeliniealdatainiegrity.AllthesPeeimenswerefixedin10%formalinandroutinelyembaddedinparaffin.E而sionTMwasused允rass叮ing小ee即ressionsoro即75andG即94，andseoredthemunderhigh一PowermieroscoPy.PutthedataintoSPSS13.0andanalyzetheeorrelati

5、onbetweentheexPressionlevelofGRP78andGRP94andeXteniofdiffereniiation，eliniealstage，dePthofinvasionandlymPhnodemetastasisofreetaladenoeareinoma.Levelofsignifieaneewassetto0.05.硕士学位论文英文摘要ResUlts1.In45easesofrectaladenoearcinoma，PositiveexPressionofG即78andGRP94wereboth24ea

6、ses(53.3%):In45easesofPerieaneeroustissuesPositiveexPressionofGRP78andGRP94were6eases(13.3%)and7Patients(15.6%):hirectaladenoearcinomaGRP78andGRP94eXPressionwassignificantlyhigherthanPerieaneeroustissues帜=16.200，P<0.01;x2=14.221，P<0.01).2.ThelevelsofGRP78andGRP94eXPress

7、ionwereeorrelatedwithexteniofdifferentiation，clinicalstage，dePthofinvasionandlymPhnodemetastasisofeaner(P<0.05orP<0.ol)，butnotwithPatient，5sex，ageandsizeoftumor(P>0.05).3.In24easesthatGRP78exPression，5Positive，thenumberofcasesGRP94eXPression，5Positivewas18:hi21easesthat

8、GRP78eXPression，snegative，thenumb叮ofeasesGRP94exPression，5Positivewas6;TheeonsistenceofGRP78andGRP94，5exPressi