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1、PegylatedLiposomalDoxorubicinConsolidationTherapyafterPlatinum/Paclitaxel【关键词】Ovarian,cancer,#8226;,Chemotherapy,#8226;,Consolidation,therapy,#8226;,Doxorubicin ABSTRACT Objective.Toassessthefeasibilityofusingpegylatedliposomaldoxorubicin(PLD)asaconsolidatio
2、ntherapyinpatients/paclitaxel-basedchemotherapy. Methods.PatientsdiagnosedallydebulkedstageIIIC/IVepithelialovariancancer/paclitaxel-basedchemotherapyg/m2every28daysforfourcycles.Asurvivalanalysisethod. Results.Ofthe30patientsenrolled,29ar-plantarerythrodyse
3、sthesiaostmontoxicity.Sixpatientsremainedclinicallyedianfolloonthsfromthepletionofprimarychemotherapy.Themedianprogression-freeintervalonths,andmedianoverallsurvivaltimeonths,otherapyadministeredtoenotherapyappearsfeasiblebasedonitstoxicityprofile.Consideringt
4、hetolerabilityofthisagent,furtherinvestigationisneededtodepicttheoptimaldoseandscheduleneededforconsolidationtherapy. INTRODUCTION Ovariancarcinomaistheleadingcauseofdeathinpatientsalignancies.Theestimatedincidenceandmortalityfor2005are22,220and16,210,respec
5、tively[1].Themajorityofendiagnosedonstrateaclinicallydefinedresponsetoplatinum/paclitaxelchemotherapy[2],ately30%50%[3,4]forpatientsallyresecteddisease.Unfortunately,theseresponsesarenotdurable,ajorityofpatientsdemonstratingdiseaserecurrence[35]. Severalstrat
6、egieshavebeenexploredtoimproveoutesandtheprognosisofpatientsizedtrialshavefailedtodemonstrateanoverallsurvivalbenefitotherapyinthesepatients,otherapyassociatedpreviousstudies,onerandomizedtrialdemonstratedanextendeddisease-freeintervalotherapyappeartobeidealca
7、ndidatesforadditionaltherapydesignedtoconsolidatetheinitialresponseandprolongthedisease-freeinterval.Theoptimalconsolidationagentshouldtargetpersistent,sloorcellsotherapeuticagentmightoffertheadvantageoferadicatingtumorcellsthatarytreatment. Theanthracyclinea
8、ntibioticdoxorubicinrepresentsonesuchagentbecauseitpossessesabroadspectrumofantineoplasticactions,ors,suchastumorsofthebreast,ovary,bladder,andthyroid.Theconventionalformulationofd
