lichen planus and hepatitis c virus (hcv) there is no association- a serological case control study

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1、Lichenplanusandhepatitiscvirus(HCV)thereisnoassociation:Aserologicalcasecontrolstudy：AdarshLataSingh,SanjeevChaudhary,A.D.Salodkar,Dr.S.R.Joharapurkar【摘要】　　［ABSTRACT］Fiftypatients(28malesand22females)gavepositiveresultinourcasecontrolstudy.Thereonbenig

2、ndermatologicaldiseaseallymphocyticinfiltrate,hypergranulosis,civattebodies［4］.HepatitisCVirus(HCV)aflavivirusismainlytransmittedviatransfusionofbloodorbloodproducts.Itisestimatedthat3%oftheplicatedasanetiologicalfactorfortheoccurrenceoflichenplanus.［1,

3、3,4］　　MATERIALANDMETHODSThispresentstudyentofDermatology,VenereologyandLeprosy,Jaeghe)anserum/plasma).TheresultsLP)selectedfromtheoutpatientdepartmentatchedforageandsexbothinstudyandcontrolgroup(Table1).Themorphologyofthelesions,types,sitesinvolved,dist

4、ributionoflesionsandassociateddiseaseallexamined.Routinelaboratorytestsonbloodincludingliverfunctiontests,kidneyfunctiontestandultrasonographyofabdomenedinallcasesofLPasptomaticdrugsasperindications.　　RESUITSThereales(56%)and22females(44%)instudygroup.T

5、hemajorityofthepatientsonthsto2years.Table1Demographicprofileofstudyandcontrolpopulation（略）　　HCVisaflavivirused,NS2,NS3,NS4a,NS4b,NS5a,andNS5bincludeRNApolymerase,cyclase,andthoseproteinsnecessaryforviralreplication.HCVparticlesarefoundinimmunelymphocyt

6、es,macrophages,anddendriticcells,asmunestimulationinLP,HCVreplicatesinepithelialcellsoflesionalandnonlesionalskininOLP(orallichenplanus).［3］AnotherstudysuggestHCVexertsanindirecteffect,mediatedpossiblybytheinductionofcytokinesandlymphokines.［5］Inonemore

7、study,thereisdetectionofHCVviralsequencesandHCVspecificCD4+and/orCD8+TlymphocytesinoralsamplesofLPpatientssuggeststhatHCVmightbeinvolvedinthedevelopmentoforallesionsviaanimmunologicalpathmunoresponse.［6］ThereisonemorefactorHLADR6thatcouldberesponsibl

8、eforthepeculiargeographicheterogeneityoftheassociationbetmainevaluatingthepotentialroleofLPindiagnosingHCVinfectionasoneofthefirstovertmarkersofpotentiallyfatalchronicliverdiseaseainly(OLP)maybesignificantlyassociatedade,asinItal