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时间:2018-10-10
《不同给药方案对细菌性阴道病疗效的比较》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、不同给药方案对细菌性阴道病疗效的比较王芳1张萍萍1尹利荣(通讯作者)1顾文玉2(1天津医科大学第二医院妇科天津300211)(2天津市中心妇产科医院妇科天津300052)【摘要】目的探讨不同的局部给药方案对细菌性阴道病的治疗效果。方法将160例BV患者随机分成四组给予阴道局部用药,A组予甲硝哇400mgQd×7d;B组予硝呋太尔250mgQd×7d;C组予甲硝哇400mgQd×7d后,予乳杆菌250mgQd×10d;D组予硝呋太尔250mgQd×7d后,予乳杆菌250mgQd×
2、10do分别于停药3天及停药2月后复查。结果各组短期有效率均高于75%,A、B、C三组有效率无明显差异;D组有效率明显高于其余三组,差异有统计学意义。A组复发率则明显高于其余三组(P<0.05)oA组无明显阴道微生态环境改善作用;B、C组只有一定的阴道微生态环境改善作用,且作用相近,两次复查差异不大。D组改善作用明显优于其余三组(P<0.05)。结论硝呋太尔联合乳杆菌方案治疗BV,在有效率、复发率及阴道微生态环境调整方面均具有明显优势。单纯应用硝呋太尔作用与甲硝唑联合乳杆菌作用相近,亦有一定的阴道微生态环境改善作用,在有效率及复发率方面
3、亦优于单用甲硝唑。单纯应用甲硝唑,无明显阴道微牛.态环境改善作用。【关键词】细菌性阴道病阴道微牛.态平衡乳酸杆菌【中图分类号】R452【文献标识码】A【文章编号】2095-1752(2014)23-0061-03EffectcomparisonofdifferenttherapeuticregimesintreatingbacterialvaginosisWangFangZhangpingpingYinLirong(DepartmentofGynecology,ThesecondhospitalofTianjinMedicalUniversity,
4、Tianjin,300211,China)Correspondingauthor:GuWenyu[Abstract]Objective:Toexploretheeffectsofdifferentlocaltherapeuticregimensintreatingbacterialvaginosis.Methods:160casesofBVpatientswererandomlydividedintofourgroupsreceivedthepartialvaginalmedicationtreatment,groupAwastreatedwith
5、metronidazole400mgQd×7d:groupBwastreatedwithNifuratel250mgQd×7d:groupCwastreatedwithmetronidazole400mgQd×7dfirstandthenLactobacillus250mgQd×10d:groupDwastreatedwithNifuratel250mgQd×7dandthentreatedwithLactobacillus250mgQd×10d.Weevaluatedthec
6、urativeeffectsafterstoppingtreatmentfor3daysandtwomonths.Result:Theshort-termeffectiveratesofallgroupswerehigherthan75%.TheeffectiverateshowednodifferencesamonggroupsA,BandC,however,Dgrouphadhigherefficiencythantheotherthreegroups.TherecurrencerateofAgroupwassignificantlyhighe
7、rthantheotherthreegroups(P<0.05).ThegroupAhadnoobviousvaginalmicroecologicalenvironmentimprovementeffect,butgroupBandChadacertaindegreeimprovementofvaginalmicroecologicalenvironment,andtheeffectsofthegroupBandCweresimilar.ThegroupDimprovedobviouslycomparedwiththeotherthreeg
8、roups(P<0.05).Conclusion:NifuratelcombinedwithLactobacillu
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