资源描述：
《4例肺上皮样血管内皮瘤临床病理研究》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、4例肺上皮样血管内皮瘤临床病理研究胡骏刘志红陈森林湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院病理科湖南长沙410013【摘要】目的：探讨肺上皮样血管内皮瘤(pulmonaryepithelioidhaemangioendothelioma,PEH)的临床病理形态学特征、免疫组化表型、诊断及鉴别诊断。方法：回顾分析4例肺穿刺活体组织检查诊断PEH患者的病理特点、免疫组织化学检查结果、临床及实验室检查结果。结果:4例PEH患者年龄30-65岁，男女比1:3,女性患者年龄均小于40岁；影像学检查示肺内结节多考虑为转移性癌或结核等，实验室检查未见明显异常。光镜下肿瘤细胞有上皮样及空泡样形态，空泡内
2、偶见红细胞，瘤细胞呈条索状、小巢状，腺样结构及不规则状分布于淀粉样或玻璃样变间质中，瘤细胞未见核分裂相，肿瘤边缘区细胞丰宮，呈息肉或肾小球样填塞于扩张的肺泡腔。肿瘤细胞表达CD31、CD34、第VIII因子相关抗原(factorVlllrelatedantigen，FVUlRAg)等血管内皮细胞标记，同时部分表达波形蛋白(vimentin)和细胞角蛋白(cytokeratin，CK)。结论：正确的诊断与鉴别诊断PEH需要结合影像学检查、组织学观察和免疫组织化学检测等方法。【关键词】肺；上皮样血管内皮瘤；病理学；免疫组化；鉴別诊断Clinicalandpathologicalstudyof4ca
3、sesofpulmonaryepithelioidhemangioendotheliomaHuJunLiuZhihongChenSenlinDepartmentofPathology,CancerHospitalofHunanProvinceTumorHospitalAffiliatedtoXiangyaMedicalCollegeofCentralSouthUniversityHunanChangsha410013[Abstract]Objective:Toinvestigatetheeffectofpulmonaryepithelioidhemangioendothelioma(pulmo
4、naryepithelioidhaemangioendothelioma,PEH)andtheclinicalpathologicalcharacteristicsandimmunohistochemicalphenotype,diagnosisanddifferentialdiagnosis.Methods:theclinicalandlaboratoryanalysisof4casesoflungpuncturebiopsyforthediagnosisofPEHpatientsandpathologicalfeatures,immunohistochemicalexaminationre
5、sults,examinationresults.Results:4casesofPEHpatientswithage30-65yearsold,maletofemaleratiowas1:3,theageoffemalepatientswerelessthan40yearsold;imagingexaminationshowedpulmonarynodulesmoreconsiderationformetastaticcarcinomaortuberculosis,laboratoryexaminationshowednoobviousabnormalities.Underlightmicr
6、oscope,tumorcellswereepithelioidandvacuolarmorphologyofredbloodcells,evenwithinthecavity,thetumorcellsshowedcordlikeandsmallnests,inamyloidorhyalinizedstromalikedistributionofadenoidstructureandirregular,tumorcellsweremitoticphase,theedgeoftumorcells,alveolarcavitywaspolyporglomeruloidpackinginexpan
7、sion.TheexpressionofCD31,CD34,factorVlllrelatedantigenoftumorcells(factorrelatedantigen,FofRAg)andendothelialcellmarkers,andexpressionofvimentin(vimentin)andcytokeratin(cytokeratin,CK).Conclusion:PEHd
