glomerulopathies –iga nephropathy iga nephropathy - umf ：肾小球疾病的免疫球蛋白iga肾病免疫球蛋白iga肾病- umf–

《glomerulopathies –iga nephropathy iga nephropathy - umf ：肾小球疾病的免疫球蛋白iga肾病免疫球蛋白iga肾病- umf–》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、Glomerulopathies–IgAnephropathyIgAnephropathy-PathogenesisGlomerulopathies–IgAnephropathyIgAnephropathy-PathogenesisMesangialIgApromotesglomerularinflammationaseriesofevents…….cancauseendstagerenaldiseaseGlomerulopathies–IgAnephropathyGlomerulopathies–IgAnephropathyIgAnephropathy-Pathog

2、enesisWhatspecificmechanismsinfluencethedepositionofIgAanditsinitiationofinflammation?Glomerulopathies–IgAnephropathyGlomerulopathies–IgAnephropathyIgAnephropathy-PathogenesistightlyTcellcontrolledprocessesinhealthmostpolymericIgAisproducedinthemucosalimmunesystemisinvolvedinmucosaldefenset

3、hebonemarrowproducesmonomericIgA,whichreachesthecirculationGlomerulopathies–IgAnephropathyGlomerulopathies–IgAnephropathyIgAnephropathy-PathogenesisinIgAnephropathysynthesisofpolymericIgAisincreasedinthebonemarrowanddecreasedinthemucosaGlomerulopathies–IgAnephropathyGlomerulopathies–IgAneph

4、ropathyGlomerulopathies–IgAnephropathyIgAnephropathy-PathogenesisYesitisGlomerulopathies–IgAnephropathyIgAnephropathy-PathogenesisWhymightthishappen?ThisprocessisverytightlyTcellregulatedInresponsetoamucosalantigen,Tcellsreachthecirculation,butwillreturntothemucosatosynthesizepolymericIgAif

5、theyexpressalpha4beta7,themucosalhomingreceptorIfontheotherhand,asystemicantigenisconfronted,Tcellswillhometothemarrowiftheyexpressthealpha4beta1systemichomingreceptorGlomerulopathies–IgAnephropathyGlomerulopathies–IgAnephropathyGlomerulopathies–IgAnephropathyIgAnephropathy-PathogenesisinIg

6、Anephropathy-theseprocessesisabnormalthereisanexaggerationofsystemichomingreceptorexpression,whichwoulddriveTcellsnotbacktothemucosabuttowardsthemarrowtheabnormalsiteofIgA1production,whichisoneofthefeaturesofIgAnephropathyGlomerulopathies–IgAnephropathyGlomerulopathies–IgAnephropathyIgAnep

7、hropathy-PathogenesisinIgAnephropathy-theseprocessesisabnormalbutnotonlythereisanexaggerationofsystemichomingreceptorexpression,whichwoulddriveTcellsnotbacktothemucosabuttowardsthemarrowtheabnormalsiteofIgA1production,whichisoneofthefeaturesofIgAnephrop