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时间:2020-09-16
《二DNA聚合酶与DNA的合成.doc》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、二、DNA聚合酶与DNA的合成 Theaccuracyoftranslationreliesonthespecificityofbasepairing.Theactualrateinbacteriaseemstobe--10-8-10-10.Thiscorrespondsto-1errorpergenomeper1000bacterialreplicationcycles,or-10-6pergenepergeneration. DNApolymerasemightimprovethespecificityofco
2、mplementarybaseselectionateither(orboth)oftwostages:·Itcouldscrutinizetheincomingbaseforthepropercomplementaritywiththetemplatebase;forexample,byspecificallyrecongnizingmatchingchemicalfeatures.Thiswouldbeapresyntheticerrorcontrol.· Oritcouldscrutinizethebasepairafte
3、rthenewbasehasbeenaddedtothechain,and,inthosecasesinwhichamistakehasbeenmade,removethemostrecentlyaddedbase.Thiswouldbeaproofreadingcontrol.
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