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《黄芪对急性肺损伤模型肺组织中细胞间粘附分子-1和血管细胞间粘附分子-1表达的调节作用.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中国药物警戒第12卷第4期2015年4月April,2015,Vo1.12,No4中图分类号:R965文献标识码:A文章编号:1672—8629(2015)04—0197—03黄芪对急性肺损伤模型肺组织中细胞间粘附分子一1和血管细胞间粘附分子一1表达的调节作用周易李火平夏光明张慧金朝霞周帆石素平(黄冈市中心医院长江大学附属黄冈医院医学实验中心,湖北黄冈438000)摘要:目的观察黄芪对急性肺损伤的保护作用并探讨肺组织中细胞间粘附分子一l(ICAM一1)、血管细胞间粘附分子一I(VCAM一1)的表达在急性肺损伤(ALI)中的作用。方法Wista
2、r大鼠30只,随机分为正常对照组、模型组和黄芪组,每组l0只。建立急性肺损伤模型,给药6h后处死所有大鼠,取出肺组织做病理学观察,并检测各组肺组织髓过氧化物酶(MP0)、超氧化物歧化酶(SOD)活性变化以及ICAM一1、VCAM一1的表达变化。结果与正常对照组相比,模型组、黄芪组的MPO活性和ICAM一1、VCAM—l表达均显著增强(P<0.05或P3、强(P<0.05)。结论黄芪能对急性肺损伤能起到有效的保护作用,其机制可能与其调节ICAM一1、VCAM一1表达和提高SOD活性有关。关键词:黄芪;急性肺损伤;髓过氧化物酶;超氧化物歧化酶;粘附分子EfectsofAstragalusonIntercellularAdhesionMolecule-1andVascularCellAdhesionMolecule-1inRatsofAcuteLungInjuryZHOUYiLIHuo-ping*XIAGuang-mingZHANGHuiJINZhao——xiaZHOUFanSHISu——ping4、(HuanggangCentralHospital,HuanggangHospitalAfiliatedtoChangjiangUniversity,HubeiHuanggang,438000,China)Abstract:0bjectiveToinvestigatetheprotectiveefectsofAstragalusonacutelunginjuryandtoexploretheroleofintercellularadhesionmolecule一1(ICAM一1)andvascularceladhesionmolecule一15、(VCAM一1)onacutelunginjuryinrats.Methods30Wistarratswererandomlydividedintocontrolgroup,modelgroupandAstragalusgroup(n=10,respectively).Allratsweresacrificed6hafteradministrationofAstragalus,removedlungtissueforpathologicalobservation,andexaminedtheexpressionofmyeloperoxidas6、e(MPoj,superoxidedismutase(SOD)activityandICAM一1,VCAM一1ineachgroup.ResultsComparedwithcontrolgroup,MPOactivityandICAIVl一1,VCAM一1expressionweresignificantlyincreasedinmodelgroupandAstragalusgroupfP<0.05orP7、一1expressionweresignificantlylowerthanthatofmodelgroup(P<0.05orP<0.01respectively).LungtissueSODactivitywassignificantlylowerafterlunginjury(P<0.05orP<0.01respectively),butitwassignificantlyenhancedaftertreatmentwithAstragalus(P<0.05).ConclusionAstragaluscanplayaprotectivee8、fectonALI,andthemechanismmayrelatetOregulatetheexpressionofICAM一1,VCAM一1andincreas
3、强(P<0.05)。结论黄芪能对急性肺损伤能起到有效的保护作用,其机制可能与其调节ICAM一1、VCAM一1表达和提高SOD活性有关。关键词:黄芪;急性肺损伤;髓过氧化物酶;超氧化物歧化酶;粘附分子EfectsofAstragalusonIntercellularAdhesionMolecule-1andVascularCellAdhesionMolecule-1inRatsofAcuteLungInjuryZHOUYiLIHuo-ping*XIAGuang-mingZHANGHuiJINZhao——xiaZHOUFanSHISu——ping
4、(HuanggangCentralHospital,HuanggangHospitalAfiliatedtoChangjiangUniversity,HubeiHuanggang,438000,China)Abstract:0bjectiveToinvestigatetheprotectiveefectsofAstragalusonacutelunginjuryandtoexploretheroleofintercellularadhesionmolecule一1(ICAM一1)andvascularceladhesionmolecule一1
5、(VCAM一1)onacutelunginjuryinrats.Methods30Wistarratswererandomlydividedintocontrolgroup,modelgroupandAstragalusgroup(n=10,respectively).Allratsweresacrificed6hafteradministrationofAstragalus,removedlungtissueforpathologicalobservation,andexaminedtheexpressionofmyeloperoxidas
6、e(MPoj,superoxidedismutase(SOD)activityandICAM一1,VCAM一1ineachgroup.ResultsComparedwithcontrolgroup,MPOactivityandICAIVl一1,VCAM一1expressionweresignificantlyincreasedinmodelgroupandAstragalusgroupfP<0.05orP7、一1expressionweresignificantlylowerthanthatofmodelgroup(P<0.05orP<0.01respectively).LungtissueSODactivitywassignificantlylowerafterlunginjury(P<0.05orP<0.01respectively),butitwassignificantlyenhancedaftertreatmentwithAstragalus(P<0.05).ConclusionAstragaluscanplayaprotectivee8、fectonALI,andthemechanismmayrelatetOregulatetheexpressionofICAM一1,VCAM一1andincreas
7、一1expressionweresignificantlylowerthanthatofmodelgroup(P<0.05orP<0.01respectively).LungtissueSODactivitywassignificantlylowerafterlunginjury(P<0.05orP<0.01respectively),butitwassignificantlyenhancedaftertreatmentwithAstragalus(P<0.05).ConclusionAstragaluscanplayaprotectivee
8、fectonALI,andthemechanismmayrelatetOregulatetheexpressionofICAM一1,VCAM一1andincreas
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