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《肝癌前体细胞snail表达与肝癌术后预后相关性研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、68肝胆外科杂志2015年2月第23卷第1期JournalofHepatobiliarySurgery,Vol,23,No.1,Feb.2015·基础研究·肝癌前体细胞snail表达与肝癌术后预后相关性研究杨知时,刘阳,夏勇,沈锋【摘要】目的本研究通过检测CD44分子和Snail蛋白在HCC中的表达,探究CD44和Snail蛋白与HCC患者临床病理因素以及术后预后的关系。方法利用免疫组化方法检测252名肝癌术后患者癌及癌旁组织CD44和Snail蛋白的表达。结果CD44阳性表达125例,见于细胞膜和细胞浆,Snail蛋白阳性表达121例见于细胞浆和细胞核。二者阳性表达均显著高于癌旁组织。
2、CD44和Snail蛋白共阳性表达89例,其1一,3一,5年生存率为49.4%,31.5%,24.7%,1一,3一,5年复发率为59.9%,76.6%,81.6%。COX多因素分析中,CD44和Snail共阳性表达是生存复发的独立危险因素。结论CD44和Snail共阳性表达与肝癌的复发和侵袭性密切相关,可作为预测肝癌患者术后预后的指标。【关键词】CD44抗原;Snail蛋白;肝细胞癌;预后评估【中图分类号】R735.7【文献标识码】A【文章编号】1006-4761(2015)01-0068-05PrognosticValueofHepatpcelluarCarcinomaprogenit
3、orcellsexpressingSnailinpatientsafterHepatectomy(YANGZhi—s,rang,XIAYong,eta1.EasternHepatobiliaryHospital,SecondMilitaryMedicalUnivertity,Shanghai200438,China)【Abstract】ObjectiveToinvestigatetheprognositicsignificanceofespressionsofCD44andSnailinpatientswithhepatocel—luarcarcinoma(HCC).MethodsDat
4、awereretrospectivelycollectedfrom252consecutivepatientswhounderwenthepatectomyforHCCbetweenJanuary2008andJune2008attheEasternHepatobiliarySurgeryHospital(EHBH).TheexpressionsofCD44andSnailwereanalyzedbyusingS-Pimmunohistochemicaltechnique.AccordingtotheexpressionsofCD44andSnail,bothpositiveexpres
5、sionsofCD44andSnailweredefinedaspositivegroup.Theprognosticriskfactorsfortumorrecurrenceandoverallsurvival(OS)ofthetwogroupwerecompared.ResultsThepositiveexpressionofCD44waslocatedinmembranesandcytoplasma,whilethatofthatofSnailwaslocatedincytoplasmaandnucleus.TheincidenceofCD44andSnailexpressionw
6、ere49.6%and48.0%respectively.whichwerestatisticallyhigherthantheexpressionsinpara—carcinomatissues.Therewere89patientswhoseexpressionsofCD4andSnailwerebothpositive.Thecomparisionofclinicalpathologicalcharacteristicsbetweenthepositiveandnegativegroupsshowedthatthepositivegrouphadahigeralanineamino
7、transferase(AIJT),proportionofmulipletumors,pTMNstaging,andpositiverateforMVI.Thepost—operative1一,3一,5-yearrecurrencerates49.4%,31.5%,24.7%forpositivegroupand74.8%,56.5%,44.3%fornegetivegroup.And1一,3一,5-yearsurvivalrat
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