欢迎来到天天文库
浏览记录
ID:54982645
大小:245.95 KB
页数:3页
时间:2020-05-07
《Th2亚群的影响-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、实用药物与临床2014年第17卷第2期PracticalPharmacyAndClinicalRemedies,2014.Vo1.17,No.2·183·血必净注射液对自发性细菌性腹膜炎患者Thl/Th2亚群的影响毛燕群,陈凯红,孙彤,裴豪[摘要]目的研究血必净注射液对乙型肝炎后肝硬化合并自发性细菌性腹膜炎患者机体Thl/Th2亚群的影响。方法将60例乙型肝炎后肝硬化合并自发性细茵性腹膜炎患者随机分成2组。对照组25例,使用抗生素和保肝等治疗;血必净组35例,在对照组治疗的基础上加用血必净注射液静脉滴注。采用流式细胞仪检测血必净注射液治疗肝硬化合并自
2、发性细菌性腹膜炎患者前后血清的Thl、Th2细胞的变化。结果两组患者Thl、Th2均于治疗第4天达到峰值(P<0.05),然后下降;治疗第8天,两组患者Thl仍高于治疗前(P<0.05),Th2水平均降低(P<0.05)。治疗第4天、第8天,血必净组的Thl均高于对照组(P<0.05),两组Th2比较差异无统计学意义(P>0.05)。两组患者治疗后Thl/Th2平衡均向Thl漂移,血必净组更加显著(P<0.01)。结论血必净可以明显促进腹膜炎患者Thl应答,改善其促炎/抗炎反应平衡,促进炎症吸收,促进病情尽早康复。[关键词】肝硬化;乙型肝炎;腹膜炎;
3、T一淋巴细胞EfectofxuebijinginjectiononTh1/Th2subsetsinpatientswithspontaneousbacte—rialperitonitisMAOYah.qun,CHENKai.hong,SUNTong,PEIHao(aDepartmentofInfectiousDis.ease,b.DepartmentofClinicalLaboratory,TheFifthPeople'sHospitalofWuxi,Wuxi214005,China)[Abstract]ObjectiveTostudytheeffe
4、ctofxuebijinginjectiononThl/Th2subsetsinpatientswithtypeBhepatitiscirrhosiswithspontaneousbacterialperitonitis.Methods60patientswithtypeBhepatitiscirrhosiswithspon—taneousbacterialperitonitiswererandomlydividedintotwogroups.Controlgroup(n=25)wastreatedwithcommonliver-protective
5、medicineandantibiotics。Xuebijinggroup(n=35)wastreatedwithnormaltreatmentcombinedwithxuebijinginjection.ThechangesofThl/Th2subsetsinpatientswithtypeBhepatitiscirhosiswithspontaneousbacterialperitonitisbeforeandafterxuebijinginjectiontherapywereobserved.ResultsThelevelofThl,Th2on
6、bothgroupsreachedthepeakatthe4thdayaftertreatment(尸<0.05),andthendecreased.Atthe8thdayaftertreatment,theThlofpatientsinbothgroupsincreased(P<0.05),andTh2decreased(P<0.05).Atthe4thand8thdayaftertreatment,theThlsubsetsofxuebijinggroupwerehigherthanthatofcontrolgroup(P<0.05),andth
7、erewasnosignificantdifferenceinTh2subsetsbetweenthetwogroups(P>0.05).ThebalanceofThl/Th2isbiasedtoThlinbothgroupsaftertreatment,andthechangesinxueb0inggroupweremoreobviousthanthoseofcontrolgroup(P<0.01).Conclu-sionXuebOinginjectioncanpromotetheThl-typeresponseinpatientswithtype
8、Bhepatitiscirrhosiswithspontane-OUSbacterialperitoniti
此文档下载收益归作者所有