[精品][经典]初诊2型糖尿病患者胰岛素泵强化治疗的长期疗效观察.doc

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1、[经典]初诊2型糖尿病患者胰岛素泵强化治疗的长期疗效观察初诊2型糖尿病患者胰岛素泵强化治疗的长期疗效观察【摘要】目的探讨初诊2型糖尿病患者短期胰岛素强化治疗后的长期疗效及长期缓解的影响因索。方法60例初诊T2dM患者，随机分为2组，胰岛素泵强化治疗组（治疗组）和口服药对照组（对照组），各30例，治疗组经2周胰岛素泵强化治疗后，给予饮食及运动干预，若血糖不达标，则加用降糖药物；对照组仅给予饮食及运动干预，如血糖不达标，予口服降糖药物，2组患者均不用曝呻烷二酮类药物。追踪观察至少1年。结果①与强化治疗前相比，强化治疗后及1年后随访的FPG、2hPG>HOMA-IR

2、、FINS、2hINS、TG、TC均明显降低，H0W-0较治疗前明显升高。②对照组治疗后及1年后随访FPG、2hPG、HOMA-IR、FINS、2hINS、TG、TC有所降低，HOMA-B较治疗前明显升高（P〈0.05）。③两组间比较：治疗组FPG、2hPG、HOMA-IR、FINS、2hTNS明显降低，HDL、HOMA-B明显升高（P〈0・05）。结论短期胰岛素泵强化治疗，可改善T2dM患者的病理生理缺陷，较肥胖的以较低胰岛素量即能达到良好控制血糖、恢复胰岛B细胞功能的初诊T2dM患者，获得长期缓解的可能性较大。【关键词】2型糖尿病；初诊；胰岛索泵强化治疗

3、A1ong-termclinicalinvestigationonintensireinsulinpumptreatmentinnewlydiagnosedtype2diabetesZHANGXiao-fan,LISu~xia,JIANGXiang-li,etal.DepartmentofEndocrinology,LuoyangEastHospitai,TheThirdAffiliatedHospitaiofHenanScienceandTechnologyUniversity,Luoyang471003,China[Abstract]ObjectiveTo

4、exploretheinfluencefactorsfor1ong-termcurativeeffectandremissionbyshort-termintensiveinsulinpumptreatmentinnewlydiagnosedtype2diabetes・MethodsAtotalof60inpatientswithnewlydiagnosedT2dMwereareredomlydevidedintotwogroup-thecureandthecontrast・Thecuregroup(30patients)receivedatwo-weekco

5、urseofinsulintherapy,andafterthat,dietandexercisetherapyweregiven,ifnotingoodglycemiccontrol,oralhypoglycemicagents(OHA)weregiven.Thecontrastgroup(30patients)receiveddietandexercisetherapy,ifnotingoodglycemiccontrol,oralhypoglycemicagents(OHA)weregiveneither・Allpatientswerefolloweda

6、tleastoneyearalong・Results①Inpostinsulintherapyversuspreinsulintheraphygroup,1yearfollow-updatashowedFPG,2hPG,HOMA-IR,FINS,2hINS,TCandTGwereallsignificantlylowerandtheHOMA-P,HDLweresignificantlyhigher(allP〈0・05~0.01)・②Thecuregroup,1yearfollow-updatashowedFPG,2hPG,HOMA-IR,FINS,2hINS,

7、TCandTGwereallsignificantlylowerandtheHOMA-P,HDLweresignificantlyhigherthanthecontrast(P<0.05).ConclusionTheshort-termintensiveinsulinpumptreatmentcanimprovethedefectofpathophisiologyofdiabetes・ThesubjectswithnewlydiagnosedT2dMwithlagewightandBMIbemoreeasytohavegoodglucosecontrolwit

8、hlowerinsulindosage