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1、DOI:10.13325/j.cnki.acta.nutr.sin.2011.05.015472ActaNutrimentaSinica,Oct.,2011,Vol.33No.5过量碘摄入对孕妇甲状腺功能及妊娠结局的影响1桑仲娜,张淑芬,魏薇,张桂芹,赵娜,张万起1(天津医科大学公共卫生学院,天津300070;河北省沧州市海兴县医院妇产科,海兴061200)【摘要】目的探讨过量碘摄入对孕妇甲状腺功能及妊娠结局的影响。方法选取河北省沧州市海兴县医院妊娠晚期孕妇210例,平均年龄(27.69±4.73)岁
2、,采集空腹晨尿及静脉血,采用砷-铈催化分光光度法测定尿碘浓度,化学发光法测定血清游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)及敏感促甲状腺激素(sTSH),并详细记录妊娠结局。结果被调查的孕妇尿碘中位数为1240.70μg/L,有84.3%的孕妇尿碘超过500μg/L,处于碘过量状态。孕妇甲状腺疾病总患病率为19.5%,其中亚临床甲状腺功能亢进、甲状腺功能减退、亚临床甲状腺功能减退的患病率分别为1.0%、2.4%、16.2%。不同尿碘水平或不同甲状腺功能的孕妇,不良妊娠结局的发生率差异没有统计
3、学意义(P>0.05),但碘过量组孕妇不良妊娠结局的发生率有升高趋势。结论孕妇摄入过量碘时,甲状腺疾病患病率较高,其中以亚临床甲状腺功能减退为主;同时不良妊娠结局的发生率也有随尿碘升高而升高的趋势,提示应重视对高碘地区孕妇碘营养状况的监测。[营养学报,2011,33(5):472-475]关键词:高碘;孕妇;尿碘;甲状腺功能;妊娠结局中图分类号:R153.1文献标识码:A文章编号:0512-7955(2011)05-0472-04EFFECTSOFEXCESSIODINEINTAKEONMATERNA
4、LTHYROIDFUNCTIONANDPREGNANCYOUTCOMES1SANGZhong-na,ZHANGShu-fen,WEIWei,ZHANGGui-qin,ZHAONa,ZHANGWan-qi1(CollegeofPublicHealth,TianjinMedicalUniversity,Tianjin300070;ObstetricsandGynecologyHospicalinHaixingCountry,CangzhouCity,Haixing061200,China)【Abstrac
5、t】ObjectiveToexploretheeffectsofexcessiodineintakeonmaternalthyroidfunctionandpregnancyoutcomes.MethodTwohundredandtenpregnantwomeninthethirdtrimesterwerecollectedfromObstetricsandGynecologyHospicalinHaixingcountry,Cangzhoucity,Hebeiprovince,andtheavera
6、geageofthemwas(27.69±4.73)years.Themorning-urineandvenousbloodwerecollected.Theurinaryiodinelevelwasexaminedbyarsenic-ceriumcatalyticcontact.Thelevelsoffreetriiodothyronine(FT3),freethyroxine(FT4)andsensitivethyroid-stimulatinghormone(sTSH)inserumwereme
7、asuredbychemiluminescence.Inaddition,pregnancyoutcomeswererecordedindetail.ResultsThemedianurinaryiodineofpregnantwomeninvestigatedwas1240.70µg/L.Theratioofpregnantwomenwithmorethan500µg/Liodineintakewas84.3%,andtheywereinthestatusofexcessiodine.Thewhol
8、eprevalencerateofthyroiddiseasewas19.5%.Theprevalenceratesofsubclinicalhyperthyroidism,hypothyroidismandsubclinicalhypothyroidismwere1.0%,2.4%and16.2%respectively.Therewerenodifferencesinadversepregnancyoutcomesinwomenwhowerediff