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1、5-FU与得宝松联合治疗瘢痕疙瘩疗效观察狄美华上海交通大学医学院附属第九人民医院整复外科门诊手术室,200011摘要[目的]:观察低浓度(0.25%)5-氟尿卩密噪与得宝松混合注射治疗瘢痕疙瘩的效果。[方法h将木组的92例患者分成治疗组和对照组两组,均行瘢痕疙瘩的全层注射,对治疗组的46例患者行5-Fu与得宝松的混合液,对对照组的46例患者行单纯得宝松注射,每隔3-4周注射,一个疗程为2-3次,随访6-12个月。[结果]:治疗组痊愈率52.2%,有效率93.5%,对照组痊愈率26.1%,有效率54.3%,1X0.01
2、,两组差异存在显著性。[结论]:低浓度5-Fu与得宝松联合治疗瘢痕疙瘩增生与复发、止痒、止痛有较好的效果。[关键词]:瘢痕疙瘩5-氟尿喘喘得宝松ABSTRACT[Objective]Toobservetheinjectiontreatmenteffectsofkeloidswithmixtureoflowconcentration(0.25%)5~Fuanddiprospan.[Methods]92patientswasdividedintotreatmentgroup(TG)thatreceivedmixturei
3、njection,andcontrolgroup(CG)thatreceivedonlydiprospan.Bothgroupswereadministcredwithfull-thickncssinjectionofkeloids,2to3times,onceevery3to4weeks,andfollowedupfor6to12months.[Results]Recoveryratewas52.2%inTGand26.1%inCG,effectiveratewas93.5%inTGand54.3%inCG.The
4、reissignificanlstatisticaldiffereneebetweenthetwogroups.5-FU与得宝松联合治疗瘢痕疙瘩疗效观察狄美华上海交通大学医学院附属第九人民医院整复外科门诊手术室,200011摘要[目的]:观察低浓度(0.25%)5-氟尿卩密噪与得宝松混合注射治疗瘢痕疙瘩的效果。[方法h将木组的92例患者分成治疗组和对照组两组,均行瘢痕疙瘩的全层注射,对治疗组的46例患者行5-Fu与得宝松的混合液,对对照组的46例患者行单纯得宝松注射,每隔3-4周注射,一个疗程为2-3次,随访6-12
5、个月。[结果]:治疗组痊愈率52.2%,有效率93.5%,对照组痊愈率26.1%,有效率54.3%,1X0.01,两组差异存在显著性。[结论]:低浓度5-Fu与得宝松联合治疗瘢痕疙瘩增生与复发、止痒、止痛有较好的效果。[关键词]:瘢痕疙瘩5-氟尿喘喘得宝松ABSTRACT[Objective]Toobservetheinjectiontreatmenteffectsofkeloidswithmixtureoflowconcentration(0.25%)5~Fuanddiprospan.[Methods]92pati
6、entswasdividedintotreatmentgroup(TG)thatreceivedmixtureinjection,andcontrolgroup(CG)thatreceivedonlydiprospan.Bothgroupswereadministcredwithfull-thickncssinjectionofkeloids,2to3times,onceevery3to4weeks,andfollowedupfor6to12months.[Results]Recoveryratewas52.2%in
7、TGand26.1%inCG,effectiveratewas93.5%inTGand54.3%inCG.Thereissignificanlstatisticaldiffereneebetweenthetwogroups.[Conelusion]Combinationoflowconcentrationof5-Fuanddiprospancangetsatisfactoryresultsforkeloidswithproliferation,recurrence,itchyandpain.[keywords]Kel
8、oids,5-Fu,diprospan刖s瘢痕疙瘩是创伤愈合领域的一个难题,其形成机理尚不清楚,冃前尚无一种理想的治疗方法,而且治疗后易于复发"3手术后发牛瘢痕疙瘩的病例也较多,瘢痕生t速度快,增牛明显,多呈瘤样。尽管激素注射治疗瘢痕疙瘩有一定的效果,但由于激素的副作用及对人体生长发育的影响,其应用受到一定的限制。5-氟廉卩密陀(5-Fu)为抗