乌司他丁联合低分子肝素治疗急性呼吸窘迫综合征疗效观察

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1、浙江大学硕士学位论文一兰望：翌5里—二———————————_————————————————————————————’————————————一一UlinastatinwithlowmolecularweightheparininthetreatmentofacuterespiratorydistresssyndromeEnglishAbstractObjectiveTostudythee虢ctSofulinastatinwithearlylowmolecularweightheparininthetreatmentofacuterespiratorydistresssyndrom

2、e(ARDS)·MethodsSelected35patientswithacuterespiratorydistresssyndromepatients，areinlinewithEuropeandtheUnitedStatesin1994proposedajointmeetingofthediagnosticcriteriaofacuterespiratorydistresssyndrome．Caseswillbeselectedrandomlydividedintotreatmentgroupandcontrolgroup，controlgroup16cases，10caSes

3、weremalesand6femaleswithameanageof35．1yearsofage；treatmentgroup19cases，12easesweremalesand7femaleswithameanageof34·7years·AfterthetwogroupsofpatientswithICUstay,ventilator-assistedventilationweretreatedwithanti．inflammatory+hormone+nutritiontherapy,thetreatmentgroupWasaddedonthisbasis，Ulinastat

4、in200，000U+normalsaline40mLintravenousinjectionofmicro．pump，3times／d，continuous5d；lowmolecularweightheparin4100U，subcutaneously2times／d，continuouslyfor1week．Twogroupsofpatientsbef．oretrea缸nentandaftertreatment，thefirst3,5，7daysvenousandarterialblood，serumdeterminationofTNF。G，IL-1D，APTT,D—dimer,

5、platelet，arterialbloodgastargets，recordingdurationofmechanicalventilationanddeaththenumberofcases，andcomparativeanalysis．ResultsBeforetreatmentcontrolgroupandtreatmentgroupTNF-。【，IL·19，theIIIdifferencewasnotstatisticallysignificant；withtheextensionoftreatmenttime，twocasesofTNF．0c，IL．113levelswe

6、redecreased，butthetreatmentgroupTNF。G，IL_1DlevelsdecreasedmoresigIlificanfly(P<0．05)。Pre-treatmentcontrolgroupandtreatmentgroupD．dimer,APTT,plateletcomparison，nostatisticallysignificantdifference；withtheextensionoftreatmenttime，twocasesofD—dimerlevelsweredecreased，butthetreatmentgroupD—dimerBod

7、ycontentdecreasedmolesignificantly(P<0．05)，APTT,nosigllificantbetweenthechangesinplatelet．Pre-treatmentcontrolgroupandtreatmentgroup，Pa02，Pa02／Fi02comparison，thewasnotstatisticallysignificant；withtheextensionoftreatmenttime，twocas