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1、胰岛素样生长因子1受体在乳腺良恶性肿瘤中的表达及其临床意义田蒙1宋曼2孙伟(通讯作者)3(1潍坊医学院山东潍坊261053)(2山东省济宁市市屮区妇幼保健院山东济宁272025)(3潍坊医学院附属医院甲乳外科山东潍坊8652150)【屮图分类号】R737.9【文献标识码】A【文章编号】1672-5085(2013)04-0124-03【摘要】目的探讨胰岛素样生长因子1受体(IGF-1R)在乳腺良恶性肿瘤屮分布和表达，探讨IGF-1R在乳腺癌治疗屮的意义。方法应用免疫组化SP方法检测IGF-1R在56例乳腺癌、24例乳腺良性病变屮的表达情况，以及在乳腺癌屮不同临床分期、组织学分级及有无淋
2、巴结转移表达的差异性。结果乳腺癌组织屮IGF-1R的阳性表达率均明显较乳腺良性病变组高(阳性率分别为80.36%、58.33)(P<0.05)o淋巴结阳性组IGF-1R表达率为90.00%(27/30),淋巴结阴性组IGF-1R表达率为65.39%(17/26)，差异有统计学意义(P<0.05)。IGF-IR的表达与患者的临床分期、肿块大小、病理类型和雌激素、孕激素、HER-2间，差异都无统计学意义(P>0.05)。结论IGF-IR在乳腺癌组织屮的高表达可能与乳腺癌的病因、发病机理有关。IGF-1R在乳腺癌起病和进展屮发挥着重要作用，并且可能对乳腺癌的转移起着相当重要的作用
3、。IGF-IR在今后的临床治疗屮将成为乳腺癌诊断和判断其预后的一个重要指标。【关键词】乳腺癌胰岛素样生长因子-1受体免疫组织化学ExpressionofInsulin-LikeGrowthFactor-1ReceptorinBenignorMalignantBreastCancerandItsClinicalSignificanceTianmeng1Songman2Sunwei3*(1、WeifangMedicalCollege,WeifangCityShandongProvince〗、MaternalandChildHealthHospitalofJiningCity,Shandon
4、gProvince,DepartmentofThyroidAndBreastSurgery,AffiliatedhospitalofWeifangMedicalCollege,WeifangCityShandongProvince)【Abstract】Objective:ToinvestigatethedistributionandexpressionofInsulin-LikeGrowthFactor-1Receptor(IGF-1R)inbenignormalignantbreastcancer,andthesignificanceduringthetreatmentofbreas
5、tcancer.Methods:ExpressionsofIGF-1Rof56breastcancers,including24casesbenign,weredetectedbySPofimmunohistochemistry.Results:ThepositiverateofexpressionofIGF-1Rinthebreastcancertissueswashigherthanthatinthebenignlesiontissue,(80.36%and58.33%,respectively)(P<0.05).Differenceonrateofexpressionbet
6、weenNL(+)andgroupNL(-)groupwasstatisticallysignificant,(90.00%and65.39%,respectively)(P<0.05).TherewasnostatisticaldifferencebetweenexpressionofIGF-1Randclinicalstage,tumorsize,pathologicaltype,estrogenandprogestogen,HER-2(P>0.05).Conclusion:TheoverexpressionofIGF-1Rinbreastcancertissueiscorr
7、elatedwiththecauseandthepathogenesis.IGF-1Rplayanveryimportantroleduringtheprogressionofbreastcancer,andmayplayanimportantroleinmetastasisofbreastcancer.IGF-1Rwillbeanimportantindicatortodiagnosebreastcanceranddetermineprogn
