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1、LiposomalDoxorubicin,Cyclophosphamide,andEtoposideandAntiretroviralTherapyforPatientswithAIDS：Sarabsa,NancyNeilb,DavidM.Aboulafiaa,c【关键词】Non-Hodgkin’s,lymphomaaUniversityofedicine,Seattle,asonMedicalCenter,Seattle,oreplexandaggressiveNHLchemotherapyregimensachievedpleteremission(CR)inonl
2、y20%58%ofHIV-infectedpatients,resultedinseverehematologictoxicity,andcontributedtoaheightenedriskoflife-threateningopportunisticinfections(OIs)in20%28%ofpatients[810].Inanefforttominimizetoxicities,theNationalInstituteofAllergyandInfectiousDiseaseAIDSClinicalTrialsGroupinitiatedatrialpar
3、ingstandard-dose-BACOD(methotrexate,bleomycin,doxorubicin,cyclophosphamide,vincristine,anddexamethasone)chemotherapyforthetreatmentofARL.Thelesser-dosearmledtosimilarresponseratesasthehigher-dosearmbutcausedsignificantlyfeinistrationofchemotherapyviaaninfusionalscheduleinacutelymphocytic
4、leukemia,Sparanoandcolleaguestreated14patients,of12hadARL,enofinfusionalcyclophosphamide,doxorubicin,andetoposide(CDE),achievingaCRin71%ofpatients,although36%ofpatientsent[12].Inthepost-HAARTera,chemotherapy-associatedOIsaregreatlydiminished[5].HootherapyandconcurrentHAARTcontinuetobeofc
5、oncern[13].Inanefforttominimizepotentialdrugdruginteractions,LittleandcolleagueschosetosuspendHAARTotherapy.TheyachievedaCRrateof74%among39patients,edianfolloonths[14].Doxorubicinisabroad-spectrumantineoplasticagentroutinelyenlistedtotreatavarietyofmalignancies,includingNHL.Adequatedosin
6、gofdoxorubicinislimitedby,amongotherthings,itsshort-andlong-termcardiotoxicsideeffects.Itsrapidclearancefromthecirculatorysystemandaycontributetoearlycardiomyopathyorlater-onsetventriculardysfunction[15].Liposomal-encapsulatedderivativesofdoxorubicinavoiduptakebythereticuloendothelialsys
7、tem.Consequently,theyremainincirculationforlongerperiodsoftime,alloorsallypermeable[16].Thelongerhalf-lifeofpolyethylene-coatedliposomalformulationsofdoxorubicinmayexplain,inpart,ia,alopecia,andcardiotoxicity[17,18].ForthetreatmentofAIDS-relatedKaposi’ssara,liposomalanthr
